DDIT3 is a key stress response regulator activated in diverse settings ranging from DNA damage, ER stress, hypoxia, and nutrient deprivation.[32] DDIT3 protein accumulates under these conditions through multifaceted effects on transcription, mRNA stability, and translation.[33] Herein, we establish that DDIT3 induction is involved in moderating the metabolic reprogramming response of cancer cells in response to limited glutamine availability. Here, DDIT3 is linked to cancer.