TNFRSF21 and neoplasm: The direct binding interface between DR6/APP was reported by Nikolov's group, which is formed by the first CRD module of DR6 and H1, H2 helices of APP‐E2 domain.[24] This DR6/APP complex implies that targeting of the surface pocket in CRD1 of DR6 by exogenous chemicals may restraint the activation of necroptosis pathway to prevent tumor metastasis.