Beside our findings that JNK promotes TGF β1 expression, TGF β1 also stimulates HSC activation and migration through activating JNK.[48, 50] Thus, A‐FABP‐JNK‐TGFβ1 may form a positive feedback loop which becomes a vicious cycle to exaggerate liver fibrosis. The gene discussed is MAPK8; the disease is Hepatic fibrosis.