Activation of JNK signaling pathway is observed in activated HSCs in patients with liver fibrosis[48] while blocking JNK activity with SP600125 inhibited HSC activation associating with decreased expression of αSMA and reduced HSC proliferation.[49] Indeed, A‐FABP promotes the transactivation of TGFβ1 by potentiating JNK/c‐Jun signaling. This evidence concerns the gene ACTA1 and Hepatic fibrosis.