CXCR4 and Hepatic fibrosis: Numerous factors derived from capillarized LSECs modulate the progression of liver fibrosis.[40] Capillarized LSEC‐derived fibronectin, EIIIA, and platelet‐derived growth factor induce HSC activation and motility.[41, 42, 43] Capillarized LSECs also mediate angiocrine signals such as FGFR1‐CXCR4 to promote fibrosis.[40] In addition to induce LSEC capillarization, the present study also identified that A‐FABP is a novel LSEC‐derived pro‐fibrotic factor which diffused into HSCs and induced the expression and secretion of TGFβ1 in a paracrine manner.