In hepatocellular carcinoma (HCC), METTL3-mediated increase in the m6A level of SOCS2 mRNA promotes degradation of this ubiquitous cytokine signaling transducer through an m6A YTHDF2-dependent mechanism; the decreased expression of SOCS2 promotes HCC progression [50]. Here, YTHDF2 is linked to hepatocellular carcinoma.