Considering the essential roles of ATP2A2 in Ca2+ signaling, mood disorders and schizophrenia in Darier’s disease patients, which are supposed to result from a pleiotropic effect of the LOF mutations in ATP2A2, a study of brain-specific KO mice for Atp2a2 would be useful to clarify the mechanisms. Here, ATP2A2 is linked to schizophrenia.