Moreover, the study of the role of 5-HT in modulation of audiogenic seizures in genetically epilepsy-prone rats showed that the administration of a neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) induced decreases in the frequency of audiogenic seizures in the animals due to the depletion of 5-HT [45]. Here, HTR5A is linked to epilepsy.