It has been observed that pro-inflammatory cytokines can stimulate insulin resistance by disrupting insulin receptor substrate (IRS) protein signaling and activate the NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) and JNK (c-Jun NH2-terminal kinase) signaling pathways, which affects insulin resistance [27]. The gene discussed is NFKB1; the disease is Insulin resistance.