The patterns of hormonal abnormalities observed were 96/186(51.6%) normogonadotrophin-hypogonadism, 49/186 (26.3%) normogonadotrophin-hypergonadism, 14/186 (7.5%) elevated FSH levels, 15/186 (8.1%) elevated LH levels, 07/186(3.8%) hypergonadotropic-hypergonadism, and 05/186 (2.7%) hyperprolactinemia (Table 6). This evidence concerns the gene PLOD1 and hypogonadism.