We obtained the intersection between the 105 potential targets and the HCC disease gene set GHCC, which revealed that YCHD directly interfered with 17 HCC-related disease targets: AKR1B10, AKR1D1, CA2, CA5A, CCL2, CYP1A2, CYP2C9, CYP2E1, CYP3A4, PPARG, PTGS2, SELE, SERPINE1, SHBG, SLC22A7, UGT1A6, and XDH. The gene discussed is SERPINE1; the disease is hepatocellular carcinoma.