Our GO and KEGG analyses based on the 62 CpG sites demonstrated that several important cellular processes, such as sodium:potassium−exchanging ATPase complex and Cul4A−RING E3 ubiquitin ligase complex, and many essential signaling pathways, including Type I diabetes mellitus, Ras signaling pathway, p53 signaling pathways, and autophagy, were identified in the system. This evidence concerns the gene TP53 and type 1 diabetes mellitus.