For example, Garnelo M et al. reported that in their cohort B cells were heavily infiltrated in HCC.19 These findings were similar to Rohr-Udilova N et al.15 Cytokines such as IL-2, IL-4, TNF-α, IL-6, IL-10, and INF-γ that are involved in B lymphocyte development can be altered in HCC patients especially with HBV infection. Here, IL6 is linked to hepatocellular carcinoma.