Moreover, the infiltrating neutrophils signals a positive feedback loop by producing chemo-attractants (such as IL-8, CXCL1, CXCL2, CXCL5, CXCL6, CXCL7, ENA-78/CXCL5, GCP-2/CXCL6) that recruit more neutrophils to tumor areas and increase their numbers.18 Nevertheless, there are only feeble data available on neutrophil infiltration in well-designed HCC studies. The gene discussed is CXCL1; the disease is hepatocellular carcinoma.