In MetS patients, serum TNF-α concentration was positively associated with the BMI (r = 0.18), serum fasting glucose (r = 0.21), and blood HbA1c (r = 0.14) and has a negative link with the serum HDL (r = -0.19) with a p-value < 0.05 demonstrating an important relation with different components of MetS presented in Fig.1. The gene discussed is TNF; the disease is metabolic syndrome.