TNF and obesity due to melanocortin 4 receptor deficiency: Simultaneously, it was negatively associated with serum HDL, which is consistent with the previous study in which the different components, including BMI, triglyceride, and obesity, were positively correlated while serum HDL was negatively correlated.18 On the other hand, some other studies documented that there was no correlation of serum TNF-α with different components of MetS, including serum lipid profile fasting blood sugar, obesity, and hypertension.