From a health standpoint, the present study showed that MA supplementation during pregnancy and lactation improved HFD-induced hepatic redox status and function, decreased LDLC content in plasma and FAS activity in liver, and inhibited NLRP3 inflammasome in mother rats and offspring, implying that MA is beneficial and promising to prevent chronic diseases or metabolic syndrome in offspring. Here, NLRP3 is linked to metabolic syndrome.