AFF3 and rheumatoid arthritis: Furthermore, a GWAS meta-analysis by Stahl et al. (2010) also confirmed the association of AFF3 gene polymorphism rs10865035 (OR: 1.12 (1.07–1.17); P = 2.0 × 10−6) with RA in a sample set of 41,282 individuals (12,307 RA cases and 28,975 controls) of European descent [18].