Also, an extended study was conducted on a sample set of 6819 RA patients and 12650 healthy controls, provided a convincing proof for the association of AFF3 gene variants rs10865035 (OR: 1.12 (1.07–1.17); P = 2.8 × 10−7) and rs1160542 (OR: 1.12 (1.05–1.20); P = 0.001) as novel susceptibility targets [13]. This evidence concerns the gene AFF3 and rheumatoid arthritis.