AFF3 and rheumatoid arthritis: Out of HLA genes, the HLA-DRB1 and associated polymorphisms are crucial in genetic susceptibility of RA, whereas other important non-HLA genes are PTPN22, IL23R, TRAF1, CTLA4, IRF5, AFF3, STAT4, CCR6, and PADI4, etc. [6–9].