Relevant to the signaling pathways, the top gene set DURCHDEWALD_SKIN_CARCINOGENESIS_UP [52] involves Podoplanin, a small membrane glycoprotein expressed in cancer-associated fibroblasts, which was reported to contribute to the progression of multiple types of tumors including pancreatic ductal adenocarcinoma [72, 73]. The gene discussed is PDPN; the disease is pancreatic ductal adenocarcinoma.