Subsequently, another group of researchers pointed out that oral treatment with HCQ (6.5 mg/kg/day) for 12 weeks lowered FBG, OGTT, insulin, homeostatic model assessment for insulin resistance (HOMA-IR), and raised β-cell function in rats fed with high-fat diet containing 46% fat, 20.3% protein, and 24% carbohydrate. This evidence concerns the gene INS and Insulin resistance.