Variables were selected as potential predictors in building macrosomic birth predictive models (Tables S2 and S3): six aneuploidy blood marker variables (AFP, hCG, uE3, inhibin A, PAPP-A, and NT), eight other continuous variables (age, WBC, SBP, DBP, Hb, cholesterol, glucose, and weight gain until 50-g OGCT), and five categorical variables (family history of diabetes, family history of hypertension, obesity group by pre-pregnancy BMI, GDM group, and parity from these tests). The gene discussed is PAPPA; the disease is gestational diabetes.