In conclusion, we determined some differentially expressed plasma proteins of the dexamethasone significant effect infants with BPD via the DIA technique, among which, LRP1 and S100A8 might be the biomarkers for BPD diagnosis and deciding the use of adjuvant corticosteroids therapy in the BPD infants. The gene discussed is S100A8; the disease is bronchopulmonary dysplasia.