Inconsistent with the observed trend in the IFNB1 level, persistent upregulation of numerous ISGs, including CXCL10, MX1, and ISG15, was observed in response to SARS-CoV-2 infection from 3 to 7 days post-infection (Figure 3B, 3C, and 3D). The gene discussed is CXCL10; the disease is infection.