This technology already uncovered potential tumor-initiating gene mutations among which are: BRAFV600E-like and RAS-like cohorts related to the MAPK signaling pathway, mutations affecting AKT1, PIK3CA, and PTEN all associated with the PI3K signaling pathway, and alterations of CHEK2, EIF1AX, and PPMID. Here, PIK3CA is linked to neoplasm.