DIAPH1 and obesity due to melanocortin 4 receptor deficiency: Thus, although the AGE/RAGE/DIAPH1 axis pattern of gene expression is not differentially affected by the degree of obesity, our findings support the notion that the degree of AGER expression associates with increased expression of adipogenic and inflammatory markers in SAT and clinical evidence of IR, further positioning RAGE as a crucial mediating gene in immunometabolism.