While increases in the PPARɣ axis have been associated with improved insulin sensitivity, the fact that neither PPARG nor PPARGC1A correlated with HOMA-IR suggest that in severe obesity, the observed increases are instead, likely a reflection of greater adipogenesis where AGER has also been implicated and may explain the strong correlation between these genes. The gene discussed is AGER; the disease is obesity due to melanocortin 4 receptor deficiency.