GO analysis revealed that secreted placental proteins uniquely altered in GDM are involved in the metabolism of proteins and extracellular matrix organization (Supplementary Data 5), those altered in PE largely function in the immune system and platelets (Supplementary Data 6) and those changed in IUGR are implicated in fibril, collagen, and laminin formation (Supplementary Data 7). The gene discussed is LAMB2; the disease is fetal growth restriction.