The alleles C-rs4129009 (p.Ile775Val) and G-rs11096957 (p.Asn241His), which decrease the risk of asthma, have been associated with elevated blood cytokine responses to a TLR1/2 agonist, most specifically Pam3CSK4-induced interleukin 6 (IL6)30. The gene discussed is TLR1; the disease is asthma.