In addition to IL4R and SMAD3, these prioritized genes are known targets of existing asthma drugs including IL6 (clazakizumab, sirukumab), TNFSF4 (oxelumab), TSLP (tezepelumab), CCR4 (mogamulizumab), IL13 (anrukinzumab, lebrikizumab, dectrekumab, and tralokinumab), IL5 (mepolizumab, reslizumab), and IL2RA (daclizumab). This evidence concerns the gene IL6 and asthma.