Target-asthma associations of 1, which is the highest possible score in Open Targets, were observed for two genes including IL4R that is the therapeutic target of dupilumab used to treat uncontrolled persistent asthma24 and SMAD3 involved in airway remodeling25 and that may mediate some actions of corticosteroids, which are the cornerstone of asthma treatment. Here, SMAD3 is linked to asthma.