The largely concordant CRISPR/RNAi screen results suggest that knocking out/down of several genes, including KAT8 and FERM2, results in widespread consequences affecting most cells’ survival, whereas other candidates (e.g., MEF2C in HL, GAB in AG) more selectively affect fractions of AD-relevant cell types, thus may serve as better targets. Here, MEF2C is linked to Alzheimer disease.