In a study by Olmos-Alonso, et al., inhibition of Colony Stimulating Factor 1 Receptor (Csf1r), another target gene of SPI1, led to decreased expression of SPI1 and microglial proliferation in APPswe/PSEN1dE9 mice, a transgenic model of AD-like pathology25. This evidence concerns the gene CSF1R and Alzheimer disease.