This observation was confirmed in other breast cancer cells including MDA-MB-231, T-47D, and MDA-MB-436, colon cancer cells DLD-1, and cervical cancer cells HeLa (Supplementary Fig. 1h–l), supporting that PRMT5-mediated AKT activation is unlikely to be cell-type dependent. Here, PRMT5 is linked to malignant colon neoplasm.