Consistent with these findings, flow cytometry analysis of tumor-derived cells showed that IL-6 knockout enhanced infiltration of CD3+ T cells into the tumors (Fig. 1d) with an increased portion of CD8+ T cells in CD45+CD3+ T cells (Fig. 1e and Supplementary Fig. 1), associated with reduced CD45+CD11b+ myeloid cells and CD45+CD11b+F4/80+ Mφs (Fig. 1f). The gene discussed is CD8A; the disease is neoplasm.