However, IL-6 neutralization moderately enhanced the ratios of CD8+ T cells in tumor-associated CD45+CD3+ T cells (Fig. 2f), but did not activate these T cells, as indicated by no increases detected in Ki67+, IFN-γ+, or CD69+ activating T cells in CD45+CD3+ T cells (Fig. 2g). The gene discussed is IL6; the disease is neoplasm.