Accordingly, elevated YAP expression is predictive of intrinsic and acquired resistance to BRAF- and MEK-inhibitors in human BRAFV600E CRCs73, lending clinical relevance to our finding that YAP is a survival factor in BA tumours, and advocating for concurrent inhibition of YAP and BRAF-MAPK signalling in this setting. The gene discussed is YAP1; the disease is breast angiosarcoma.