This is particularly intriguing since, in the same work, Chandley and colleagues81 observed elevations in NMDA receptor subunit gene expression in MDD patients when compared to controls, but no expression changes in the moderately expressed GluA1 receptor (GRIA1) or the highly expressed GluA2 (GRIA2) and GluA4 (GRIA4) of the AMPA ionotropic family, nor in any of the receptor subunits (GRIK1, GRIK3 and GRIK5) from the kainate ionotropic class of receptors. This evidence concerns the gene GRIA4 and major depressive disorder.