According to this background, Shibata et al.58 investigated the mRNA expression levels of HIF-1 (α and β) and its target genes (VEGF, GLUT1, PGK1, PFKFB3 and LDHA) in peripheral white blood cells of patients affected by MDD and bipolar disorder (BPD). This evidence concerns the gene SLC2A1 and major depressive disorder.