In this regard, Lukic et al.35 provided evidence that MDD is characterized by an upregulation of redox-sensitive transcriptional factors (Nrf2 and NF-κB) and AOEs (MnSOD, CuZnSOD and CAT), indicating a pro-oxidative state in the PBMC of MDD patients. The gene discussed is NFE2L2; the disease is major depressive disorder.