To this purpose, Roy et al.94 have studied the mRNA levels of stress-related genes, such as BDNF, Nuclear Receptor Subfamily 3 Group C Member 1 (NR3C1 or GR), FK506 Binding Protein 5 (FKBP5), Corticotropin Releasing Hormone Binding Protein (CRHBP), and Corticotropin Releasing Hormone Receptor 1 (CRHR1) in PBMC of MDD patients and their matched controls. This evidence concerns the gene NR3C1 and major depressive disorder.