Notably, the binding of TFEB to the promoter of CTSB but not LAMP1 was suppressed in LPS-treated cultured PTECs measured by ChIP assay, suggesting that TFEB regulated CTSB at a transcription level, while having a transcription-independent effect on LAMP1 in renal tubular cells during septic AKI. The gene discussed is LAMP1; the disease is acute kidney injury.