Post-hoc lookups of known ALS genes that might be associated with TD revealed that an F-Box protein-encoding gene FBXO15, chemo/neurokine encoding gene FAM19A1, and neuropeptide encoding gene, NPS. Proteinopathies commonly implicated in neurodegenerative conditions have been proposed to also underlie TD61,62. This evidence concerns the gene FBXO15 and proteostasis deficiencies.