CD14 and Sepsis: Upon culturing HSPCs isolated from healthy human bone marrow with plasma from patients with urosepsis (urinary tract infection with organ dysfunction) or healthy controls, we found that sepsis plasma stimulated the production of monocytes and neutrophils more than healthy plasma did (P = 0.025 and 0.004 for CD34−CD11b+CD14+ and CD34−CD11b+CD15+ cells, respectively; Fig. 2A).