Consistent with this finding, we found that expression of the MS1 gene module in monocytes correlated negatively with the fraction and absolute numbers of CD4 T cells, but not CD8 T cells, among total PBMCs from patients with sepsis compared to controls from our earlier study (Pearson r = −0.58 and −0.59, P < 0.01; Fig. 4D) (23). This evidence concerns the gene CD8A and Sepsis.