These genes are part of the DAM signature initially identified in 5XFAD mouse model, however, their characteristics were since further validated in other AD mouse models, such as the PS2APP and APP/PS1 (Kamphuis et al, 2016; Deczkowska et al, 2018; Friedman et al, 2018; Mrdjen et al, 2018). This evidence concerns the gene APP and Alzheimer disease.