In addition, there was a significant increase in SASP-related inflammatory cytokines (IL-6, IL-10, EOTAXIN/CCL11, and TNFα) in the serum of old NME mice compared with young NME mice (Fig. 3C), which is consistent with preexisting SnCs creating an environment that contributes to hyperinflammation upon infection. Here, CCL11 is linked to infection.