In this study, correlations between cognitive function and levels of serum thyroid hormones (F-T3 and F-T4) and lipid metabolism-regulated molecules (apolipoprotein E (APOE) and apolipoprotein A1 (APOA1), insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein 7 (IGFBP7)) in SLE patients were evaluated. This evidence concerns the gene IGF1 and systemic lupus erythematosus.