Additionally, B cell hyperreactivity could induce an accumulation of autoreactive plasma cells [68] and secrete a variety of autoantibodies, including anti-dsDNA, anti-Sm, anti-Ro, anti-SSA, anti-SSB, anti-Rib-P, and anti-β2-GPI, to mediate the occurrence of SLE [69]. This evidence concerns the gene CALR and systemic lupus erythematosus.