Biologically, NB is not characterized by a high rate of mutations but rather by frequent recurrent chromosomal aberrations, some of which can be used as genetic markers providing prognostic information: whole-genome duplication is usually associated with a good outcome, whereas segmental chromosomal aberrations like MYCN amplification (MNA) and 11q deletion are commonly associated with a poor prognosis [6, 7]. This evidence concerns the gene MYCN and neuroblastoma.