Based on multiple prognosis factors, such as age at diagnosis, the stage of the disease, histology, grade of differentiation, MYCN status, genomic profile, and ploidy, the International Neuroblastoma Risk Group (INRG) classification system [6, 8] determines four main categories of patients: very-low-risk, low-risk, intermediate-risk, and high-risk NB patients have estimated 5-year event-free survival rates of > 85%, > 75% to < 85%, > 50% to < 75%, and < 50%, respectively [8]. This evidence concerns the gene MYCN and neuroblastoma.