Interestingly, NB susceptibility genes were recently identified in the germline DNA of a patient with sporadic NB, suggesting that common germline polymorphisms with low penetrance (i.e., NBAT-1, CASC15, BARD1, LMO1, HSD17B12, DUSP12, LIN28B, HACE1, SPAG16, NEFL, MLF1/RSRC1, CPZ, CDKN1B, SLC16A1, MSX1, MMP20, KIF15) or more rare variants with higher penetrance (i.e., ALK, BARD1, CHEK2, AXIN2, TP53, APC, BRCA2, SDHB, SMARCA4, LZTR1, BRCA1) may also have a relevant role in NB carcinogenesis [17, 18]. This evidence concerns the gene CASC15 and neuroblastoma.