SDHB and neuroblastoma: Additionally, NB has been reported to be associated with diseases well-known to predispose cancer, such as Li Fraumeni syndrome (TP53 mutations) [42], familial paraganglioma/pheochromocytoma (SDHB mutations) [43], and Beckwith–Wiedemann syndrome (CDKN1C mutations or loss of expression) [44].