Additionally, well-known specific TSGs and genomic stability regulators such as retinoic acid receptor beta2 (RARβ2), cyclin-dependent kinase inhibitor2A (CDNK2A), Ras association domain family member1A (RASSF1A), homeobox gene D3 (HOXD3), O6-methylguanine DNA methyltransferase (MGMT), cyclin2 (CCND2), prostaglandin-endoperoxide synthase 2 (PTGS2), and glutathione S-transferase Pi1 (GSTP1) were also commonly silenced by promoter methylation in PCa (Fig. 2A). Here, PTGS2 is linked to posterior cortical atrophy.