MAPT and amyloidosis: We next analysed microglial activation in subsequent stages of the ATN continuum, by comparing control mice (F−/T−), 5xFAD mice (F+/T−), which exhibited only amyloid pathology, and tau-seeded 5xFAD/PS19 double transgenic mice (F+/T+), which exhibited both amyloid and tau pathology (Fig. 3a, b).