Therefore, in our study, our team synthesized polyethylene glycol (PEG)-coated USPIO nanoparticles-coupled sLex (USPIO-PEG-sLex) nanocomplex (Fig. 1), which had an outstanding dispersion, high stability, excellent T2 relaxation, and could targrt the E-selectin expression of tumor neovascular endothelial cells, and the USPIO-PEG-sLex were performed for MRI and PTT of NPC nude mouse xenograft models as a nanotheranostic platform. This evidence concerns the gene SELE and nasopharyngeal carcinoma.