Thus, after knowing whether the expression of CD146 interacts with the progression of OS, it is necessary to know the changes of CD146 expression of tumor cells under hyperoxia (HO), low oxygen (LO), high glucose (HG) and low glucose (LG) conditions, so as to provide a reference for predicting the potential internal relationship and prognosis between tumor and various complications. The gene discussed is MCAM; the disease is neoplasm.