Loss of 8p involving the DLC1, CCDC25, ELP3, PROSC, SORBS3, SH2D4A genes associated with poor outcomes for HCC; in vitro and in vivo analysis indicated that the PROCS, SH2D4A and SORBS3 genes have tumor-suppressive activities and the DLC1 gene is a known tumor suppressor gene [9]. Here, SH2D4A is linked to hepatocellular carcinoma.