SPRED1 and melanoma: Hayward and colleagues [21] found that acral and mucosal melanomas were dominated by structural changes and mutation signatures of unknown etiology that were not previously identified in melanoma, such as in SF3B1. Newell and colleageues [22] also found that mucosal melanomas had a low point mutation burden and high numbers of structural variants; the significantly mutated genes in mucosal melanomas included NRAS, BRAF, NF1, KIT, SF3B1, TP53, SPRED1, ATRX, HLA-A and CHD8 genes.