AKT1 and cancer: In addition, CST1 had also been reported to modulate the development of cancers via targeting multiple signaling pathways (PI3K, phosphatidylinositol 3‐kinase), such as ERα/PI3K/AKT/ERα loopback pathway [38], Wnt pathway [39] and so on, but future work was still needed to investigate the molecular mechanisms by which CST1 facilitated the development of PTC.