Nuclear p‐STAT3 was detected at significantly higher levels in the tumor vasculature of mice treated with SHP099, AMG386, or SHP099+AMG386 compared to control (Fig 7A and B), but the increase in p‐STAT3 induced by AMG386 alone or with SHP099, was quantitatively lower than induced by SHP099 alone (P < 0.001 both comparisons). This evidence concerns the gene STAT3 and neoplasm.