Based on our previous experiments showing that tyrosine‐phosphorylated (p)‐EphrinB2/SHP2 signaling delays the physiological involution of hyaloid vessels by blocking pro‐apoptotic STAT signaling, we now examined whether EphrinB is active in the tumor vasculature and contributes to preserving the viability of tumor vessels. Here, PTPN11 is linked to neoplasm.