Some of the residual tumor vessels appeared damaged and leaky (Figs 6G and EV4F) and not viable based on the presence of cleaved caspase 3+/CD31+ endothelial cells lining vessels (Figs 6H and EV4F) and detection of vascular sleeves (Figs 6J and EV4G). Here, CASP3 is linked to neoplasm.