Here, we identified Ang2/TIE2 as a pro‐angiogenic pathway active in B16F10 tumors, which secrete Ang2 (Abdul Pari et al,2020) and found that Ang1/2‐TIE2 neutralization enhances the efficacy of SHP099 as an anti‐angiogenic and anti‐cancer agent. This evidence concerns the gene ANGPT2 and cancer.