For instance, TRIM33 binds to DHX33 and boosts its ubiquitylation at Lys63, resulting in the activation of the NLRP3 inflammasome (Weng, 2014); TRIM33 targets β‐catenin and mediates its ubiquitylation and degradation to restrain the proliferation of various types of cancer cells (Xue, 2015). The gene discussed is DHX33; the disease is cancer.