In the presence of oxidative stress, the expression of TRIM33 in osteoblasts was lessened and the lessened TRIM33 further boosted the acetylation modification of FOXO3a by CBP, thereby boosting the ubiquitination and degradation of FOXO3a protein, and boosting the oxidative stress and apoptosis of osteoblasts and aggravating osteoporosis. The gene discussed is FOXO3; the disease is osteoporosis.