HIF1A and colorectal cancer: When oxygen is not present, Hif‐1α is stabilized and translocated to the nucleus to bind to hypoxia‐response elements.(77) Cox2 has been identified as a hypoxia responsive gene in colorectal cancer.(78) Authors of the work with Cox2 and iPTH were interested in its role regulating prostaglandin production, but it is possible that part of the effect of deleting this gene is affected by changes in energy metabolism.