FOXO3 and metabolic syndrome: Although the protective effects of VitD3 and IL-10, as well as the role of the AMPKα/SIRT1/FOXO3a signaling pathway, have been studied both in vivo and in vitro against oxidative stress, aging, and metabolic syndrome, we have demonstrated the protective effects of VitD3 against DOX-induced senescence in HAECs by upregulation of IL-10.