Functional studies such as the ChIP assay to identify the binding activity of these genotypes or luciferase reporter assay to test the function of these polymorphisms, especially the NF-kB binding site activity in genotype AA of rs3774932 or genotype CC of rs3774937, would be helpful to further elucidate the potential effects of these genotypes on gene transcriptional regulation and expression, consequently affecting the NF-kB pathway activation and/or susceptibility to AMD pathology. The gene discussed is NFKB1; the disease is age-related macular degeneration.