BGLAP and obesity due to melanocortin 4 receptor deficiency: Obesity was not associated with any difference in osteocalcin levels between individuals with and without obesity (S7 Fig), except in studies combining men and women (n = 9: MD = -3.86 ng/ml, 95% CI: -6.78, -0.95, P = 0.009, I2 = 97%).