While TGFβ demonstrates a strong impact on the main functions of fibroblasts, including proliferation, cytokine secretion, cytoskeletal structure rearrangement and ECM deposition and remodeling [20, 26–28], its actions on fibroblasts within complex and dynamic tumor microenvironment, where it can crosstalk with other signaling pathways, still not fully dissected. Here, TGFB1 is linked to neoplasm.