CD40 and pancreatic ductal adenocarcinoma: To do this, we analyzed serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels collected on patients with pancreatic ductal adenocarcinoma (PDAC) treated on a clinical trial with the fully human agonist CD40 antibody CP-870,893 in combination with gemcitabine chemotherapy (16).